Arizona Cardinals vs San Francisco 49ers
Series timeline
▲ Arizona Cardinals ahead (peak +4)
▼ San Francisco 49ers ahead (peak +11)
Chicago Cardinals St. Louis Cardinals Arizona Cardinals San Francisco 49ers Tie Postseason One meeting per cell
Longest streaks: Arizona Cardinals 8 (2015–2018), San Francisco 49ers 5 (1980–1987). Current: San Francisco 49ers 3.
Splits
| Split | Arizona Cardinals record |
|---|---|
| Regular season | 31-39 |
| Hosted by Arizona Cardinals | 16-17 |
| Hosted by San Francisco 49ers | 15-22 |
| Last 10 seasons (2017 to 2026) | 9-10 |
| Largest Arizona Cardinals win | 47-7 (2015) |
| Largest San Francisco 49ers win | 50-14 (2003) |
In the record book
- Longest winning streaks#100 in NFL
- Longest active streaks#69 in NFL
Every meeting
2020s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 2026 | Sep 27, 2026 | San Francisco 49ers | 36-30 | at San Francisco 49ers | Week 3 |
| 2025 (0-2) | Sep 21, 2025 | San Francisco 49ers | 16-15 | at San Francisco 49ers | Week 3 |
| Nov 16, 2025 | San Francisco 49ers | 41-22 | at Arizona Cardinals | Week 11 | |
| 2024 (2-0) | Oct 6, 2024 | Arizona Cardinals | 24-23 | at San Francisco 49ers | Week 5 |
| Jan 5, 2025 | Arizona Cardinals | 47-24 | at Arizona Cardinals | Week 18 | |
| 2023 (0-2) | Oct 1, 2023 | San Francisco 49ers | 35-16 | at San Francisco 49ers | Week 4 |
| Dec 17, 2023 | San Francisco 49ers | 45-29 | at Arizona Cardinals | Week 15 | |
| 2022 (0-2) | Nov 21, 2022 | San Francisco 49ers | 38-10 | at Arizona Cardinals | Week 11 |
| Jan 8, 2023 | San Francisco 49ers | 38-13 | at San Francisco 49ers | Week 18 | |
| 2021 (2-0) | Oct 10, 2021 | Arizona Cardinals | 17-10 | at Arizona Cardinals | Week 5 |
| Nov 7, 2021 | Arizona Cardinals | 31-17 | at San Francisco 49ers | Week 9 | |
| 2020 (1-1) | Sep 13, 2020 | Arizona Cardinals | 24-20 | at San Francisco 49ers | Week 1 |
| Dec 26, 2020 | San Francisco 49ers | 20-12 | at Arizona Cardinals | Week 16 |
2010s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 2019 (0-2) | Oct 31, 2019 | San Francisco 49ers | 28-25 | at Arizona Cardinals | Week 9 |
| Nov 17, 2019 | San Francisco 49ers | 36-26 | at San Francisco 49ers | Week 11 | |
| 2018 (2-0) | Oct 7, 2018 | Arizona Cardinals | 28-18 | at San Francisco 49ers | Week 5 |
| Oct 28, 2018 | Arizona Cardinals | 18-15 | at Arizona Cardinals | Week 8 | |
| 2017 (2-0) | Oct 1, 2017 | Arizona Cardinals | 18-15 | at Arizona Cardinals | Week 4 |
| Nov 5, 2017 | Arizona Cardinals | 20-10 | at San Francisco 49ers | Week 9 | |
| 2016 (2-0) | Oct 6, 2016 | Arizona Cardinals | 33-21 | at San Francisco 49ers | Week 5 |
| Nov 13, 2016 | Arizona Cardinals | 23-20 | at Arizona Cardinals | Week 10 | |
| 2015 (2-0) | Sep 27, 2015 | Arizona Cardinals | 47-7 | at Arizona Cardinals | Week 3 |
| Nov 29, 2015 | Arizona Cardinals | 19-13 | at San Francisco 49ers | Week 12 | |
| 2014 (1-1) | Sep 21, 2014 | Arizona Cardinals | 23-14 | at Arizona Cardinals | Week 3 |
| Dec 28, 2014 | San Francisco 49ers | 20-17 | at San Francisco 49ers | Week 17 | |
| 2013 (0-2) | Oct 13, 2013 | San Francisco 49ers | 32-20 | at San Francisco 49ers | Week 6 |
| Dec 29, 2013 | San Francisco 49ers | 23-20 | at Arizona Cardinals | Week 17 | |
| 2012 (0-2) | Oct 29, 2012 | San Francisco 49ers | 24-3 | at Arizona Cardinals | Week 8 |
| Dec 30, 2012 | San Francisco 49ers | 27-13 | at San Francisco 49ers | Week 17 | |
| 2011 (1-1) | Nov 20, 2011 | San Francisco 49ers | 23-7 | at San Francisco 49ers | Week 11 |
| Dec 11, 2011 | Arizona Cardinals | 21-19 | at Arizona Cardinals | Week 14 | |
| 2010 (0-2) | Nov 29, 2010 | San Francisco 49ers | 27-6 | at Arizona Cardinals | Week 12 |
| Jan 2, 2011 | San Francisco 49ers | 38-7 | at San Francisco 49ers | Week 17 |
2000s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 2009 (0-2) | Sep 13, 2009 | San Francisco 49ers | 20-16 | at Arizona Cardinals | Week 1 |
| Dec 14, 2009 | San Francisco 49ers | 24-9 | at San Francisco 49ers | Week 14 | |
| 2008 (2-0) | Sep 7, 2008 | Arizona Cardinals | 23-13 | at San Francisco 49ers | Week 1 |
| Nov 10, 2008 | Arizona Cardinals | 29-24 | at Arizona Cardinals | Week 10 | |
| 2007 (0-2) | Sep 10, 2007 | San Francisco 49ers | 20-17 | at San Francisco 49ers | Week 1 |
| Nov 25, 2007 | San Francisco 49ers | 37-31 | at Arizona Cardinals | Week 12 | |
| 2006 (2-0) | Sep 10, 2006 | Arizona Cardinals | 34-27 | at Arizona Cardinals | Week 1 |
| Dec 24, 2006 | Arizona Cardinals | 26-20 | at San Francisco 49ers | Week 16 | |
| 2005 (2-0) | Oct 2, 2005 | Arizona Cardinals | 31-14 | at Arizona Cardinals | Week 4 |
| Dec 4, 2005 | Arizona Cardinals | 17-10 | at San Francisco 49ers | Week 13 | |
| 2004 (0-2) | Oct 10, 2004 | San Francisco 49ers | 31-28 | at San Francisco 49ers | Week 5 |
| Dec 12, 2004 | San Francisco 49ers | 31-28 | at Arizona Cardinals | Week 14 | |
| 2003 (1-1) | Oct 26, 2003 | Arizona Cardinals | 16-13 | at Arizona Cardinals | Week 8 |
| Dec 7, 2003 | San Francisco 49ers | 50-14 | at San Francisco 49ers | Week 14 | |
| 2002 (0-2) | Oct 27, 2002 | San Francisco 49ers | 38-28 | at San Francisco 49ers | Week 8 |
| Dec 21, 2002 | San Francisco 49ers | 17-14 | at Arizona Cardinals | Week 16 | |
| 2000 | Oct 1, 2000 | San Francisco 49ers | 27-20 | at San Francisco 49ers | Week 5 |
1990s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 1999 | Sep 27, 1999 | San Francisco 49ers | 24-10 | at Arizona Cardinals | Week 3 |
| 1993 | Oct 24, 1993 | San Francisco 49ers | 28-14 | at San Francisco 49ers | Week 8 |
| 1992 | Nov 1, 1992 | Arizona Cardinals | 24-14 | at Arizona Cardinals | Week 9 |
| 1991 | Nov 17, 1991 | San Francisco 49ers | 14-10 | at San Francisco 49ers | Week 12 |
1980s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 1988 | Nov 6, 1988 | Arizona Cardinals | 24-23 | at Arizona Cardinals | Week 10 |
| 1987 | Oct 18, 1987 | San Francisco 49ers | 34-28 | at San Francisco 49ers | Week 6 |
| 1986 | Nov 9, 1986 | San Francisco 49ers | 43-17 | at San Francisco 49ers | Week 10 |
| 1983 | Sep 18, 1983 | San Francisco 49ers | 42-27 | at St. Louis Cardinals | Week 3 |
| 1982 | Nov 21, 1982 | San Francisco 49ers | 31-20 | at St. Louis Cardinals | Week 11 |
| 1980 | Sep 14, 1980 | San Francisco 49ers | 24-21 | at San Francisco 49ers | Week 2 |
1970s
| Season | Date | Winner | Score | Site | Round |
|---|---|---|---|---|---|
| 1979 | Dec 2, 1979 | St. Louis Cardinals | 13-10 | at St. Louis Cardinals | Week 14 |
| 1978 | Nov 12, 1978 | St. Louis Cardinals | 16-10 | at San Francisco 49ers | Week 11 |
| 1976 | Oct 31, 1976 | St. Louis Cardinals | 23-20 | at St. Louis Cardinals | Week 8 |
| 1974 | Oct 6, 1974 | St. Louis Cardinals | 34-9 | at San Francisco 49ers | Week 4 |
| 1971 | Oct 24, 1971 | San Francisco 49ers | 26-14 | at St. Louis Cardinals | Week 6 |