Buffalo Bills vs San Francisco 49ers

Buffalo Bills 8

Buffalo Bills leads 8-6

wins

1972 to 2024

Buffalo Bills have won 3 straight

San Francisco 49ers 6

Series timeline

▲ Buffalo Bills ahead (peak +2) ▼ San Francisco 49ers ahead (peak +1)

Buffalo Bills San Francisco 49ers Tie Postseason One meeting per cell

Longest streaks: Buffalo Bills 3 (2016–2024), San Francisco 49ers 2 (1983–1989). Current: Buffalo Bills 3.

Split	Buffalo Bills record
Regular season	8-6
Hosted by Buffalo Bills	4-2
Hosted by San Francisco 49ers	4-4
Last 10 seasons (1992 to 2024)	6-4
Largest Buffalo Bills win	41-7 (2004)
Largest San Francisco 49ers win	45-3 (2012)

2020s

Season	Date	Winner	Score	Site	Round
2024	Dec 1, 2024	Buffalo Bills	35-10	at Buffalo Bills	Week 13
2020	Dec 7, 2020	Buffalo Bills	34-24	at San Francisco 49ers	Week 13

2010s

Season	Date	Winner	Score	Site	Round
2016	Oct 16, 2016	Buffalo Bills	45-16	at Buffalo Bills	Week 6
2012	Oct 7, 2012	San Francisco 49ers	45-3	at San Francisco 49ers	Week 5

2000s

Season	Date	Winner	Score	Site	Round
2008	Nov 30, 2008	San Francisco 49ers	10-3	at Buffalo Bills	Week 13
2004	Dec 26, 2004	Buffalo Bills	41-7	at San Francisco 49ers	Week 16
2001	Dec 2, 2001	San Francisco 49ers	35-0	at San Francisco 49ers	Week 12

1990s

Season	Date	Winner	Score	Site	Round
1998	Oct 4, 1998	Buffalo Bills	26-21	at Buffalo Bills	Week 5
1995	Dec 3, 1995	San Francisco 49ers	27-17	at San Francisco 49ers	Week 14
1992	Sep 13, 1992	Buffalo Bills	34-31	at San Francisco 49ers	Week 2

1980s

Season	Date	Winner	Score	Site	Round
1989	Dec 17, 1989	San Francisco 49ers	21-10	at San Francisco 49ers	Week 15
1983	Dec 11, 1983	San Francisco 49ers	23-10	at Buffalo Bills	Week 15
1980	Dec 21, 1980	Buffalo Bills	18-13	at San Francisco 49ers	Week 16

1970s

Season	Date	Winner	Score	Site	Round
1972	Sep 24, 1972	Buffalo Bills	27-20	at Buffalo Bills	Week 2