Carolina Panthers vs San Francisco 49ers

Carolina Panthers 13

Carolina Panthers leads 13-11

wins

1995 to 2025

San Francisco 49ers have won 3 straight

San Francisco 49ers 11

Series timeline

▲ Carolina Panthers ahead (peak +5) ▼ San Francisco 49ers ahead (peak +2)

Carolina Panthers San Francisco 49ers Tie Postseason One meeting per cell

Longest streaks: Carolina Panthers 4 (1999–2000), San Francisco 49ers 4 (1997–1998). Current: San Francisco 49ers 3.

Split	Carolina Panthers record
Regular season	13-10
Postseason	0-1
Hosted by Carolina Panthers	6-6
Hosted by San Francisco 49ers	7-5
Last 10 seasons (2001 to 2025)	6-6
Largest Carolina Panthers win	23-3 (2017)
Largest San Francisco 49ers win	51-13 (2019)

Season	Date	Winner	Score	Site	Round
2013	Jan 12, 2014	San Francisco 49ers	23-10	at Carolina Panthers	Divisional Round

2020s

Season	Date	Winner	Score	Site	Round
2025	Nov 24, 2025	San Francisco 49ers	20-9	at San Francisco 49ers	Week 12
2022	Oct 9, 2022	San Francisco 49ers	37-15	at Carolina Panthers	Week 5

2010s

Season	Date	Winner	Score	Site	Round
2019	Oct 27, 2019	San Francisco 49ers	51-13	at San Francisco 49ers	Week 8
2017	Sep 10, 2017	Carolina Panthers	23-3	at San Francisco 49ers	Week 1
2016	Sep 18, 2016	Carolina Panthers	46-27	at Carolina Panthers	Week 2
2013 (1-1)	Nov 10, 2013	Carolina Panthers	10-9	at San Francisco 49ers	Week 10
	Jan 12, 2014	San Francisco 49ers	23-10	at Carolina Panthers	Divisional Round Postseason
2010	Oct 24, 2010	Carolina Panthers	23-20	at Carolina Panthers	Week 7

2000s

Season	Date	Winner	Score	Site	Round
2007	Dec 2, 2007	Carolina Panthers	31-14	at Carolina Panthers	Week 13
2004	Nov 14, 2004	Carolina Panthers	37-27	at San Francisco 49ers	Week 10
2001 (0-2)	Oct 7, 2001	San Francisco 49ers	24-14	at San Francisco 49ers	Week 4
	Nov 18, 2001	San Francisco 49ers	25-22	at Carolina Panthers	Week 10
2000 (2-0)	Sep 10, 2000	Carolina Panthers	38-22	at San Francisco 49ers	Week 2
	Oct 22, 2000	Carolina Panthers	34-16	at Carolina Panthers	Week 8

1990s

Season	Date	Winner	Score	Site	Round
1999 (2-0)	Oct 17, 1999	Carolina Panthers	31-29	at San Francisco 49ers	Week 6
	Dec 18, 1999	Carolina Panthers	41-24	at Carolina Panthers	Week 15
1998 (0-2)	Nov 8, 1998	San Francisco 49ers	25-23	at San Francisco 49ers	Week 10
	Dec 6, 1998	San Francisco 49ers	31-28	at Carolina Panthers	Week 14
1997 (0-2)	Sep 29, 1997	San Francisco 49ers	34-21	at Carolina Panthers	Week 5
	Nov 16, 1997	San Francisco 49ers	27-19	at San Francisco 49ers	Week 12
1996 (2-0)	Sep 22, 1996	Carolina Panthers	23-7	at Carolina Panthers	Week 4
	Dec 8, 1996	Carolina Panthers	30-24	at San Francisco 49ers	Week 15
1995 (1-1)	Nov 5, 1995	Carolina Panthers	13-7	at San Francisco 49ers	Week 10
	Dec 10, 1995	San Francisco 49ers	31-10	at Carolina Panthers	Week 15