Indianapolis Colts vs San Francisco 49ers

Indianapolis Colts 27

Indianapolis Colts leads 27-19

wins

1953 to 2025

San Francisco 49ers won the last meeting

San Francisco 49ers 19

Series timeline

▲ Indianapolis Colts ahead (peak +10) ▼ San Francisco 49ers ahead (peak +4)

Baltimore Colts Indianapolis Colts San Francisco 49ers Tie Postseason One meeting per cell

Longest streaks: Baltimore Colts 13 (1962–1968), San Francisco 49ers 5 (1969–1989). Current: San Francisco 49ers 1.

Split	Indianapolis Colts record
Regular season	27-19
Hosted by Indianapolis Colts	15-8
Hosted by San Francisco 49ers	12-11
Last 10 seasons (1989 to 2025)	6-4
Largest Indianapolis Colts win	41-7 (1967)
Largest San Francisco 49ers win	45-14 (1953)

2020s

Season	Date	Winner	Score	Site	Round
2025	Dec 22, 2025	San Francisco 49ers	48-27	at Indianapolis Colts	Week 16
2021	Oct 24, 2021	Indianapolis Colts	30-18	at San Francisco 49ers	Week 7

2010s

Season	Date	Winner	Score	Site	Round
2017	Oct 8, 2017	Indianapolis Colts	26-23	at Indianapolis Colts	Week 5
2013	Sep 22, 2013	Indianapolis Colts	27-7	at San Francisco 49ers	Week 3

2000s

Season	Date	Winner	Score	Site	Round
2009	Nov 1, 2009	Indianapolis Colts	18-14	at Indianapolis Colts	Week 8
2005	Oct 9, 2005	Indianapolis Colts	28-3	at San Francisco 49ers	Week 5
2001	Nov 25, 2001	San Francisco 49ers	40-21	at Indianapolis Colts	Week 11

1990s

Season	Date	Winner	Score	Site	Round
1998	Oct 18, 1998	San Francisco 49ers	34-31	at San Francisco 49ers	Week 7
1995	Oct 15, 1995	Indianapolis Colts	18-17	at Indianapolis Colts	Week 7

1980s

Season	Date	Winner	Score	Site	Round
1989	Sep 10, 1989	San Francisco 49ers	30-24	at Indianapolis Colts	Week 1
1986	Oct 5, 1986	San Francisco 49ers	35-14	at San Francisco 49ers	Week 5

1970s

Season	Date	Winner	Score	Site	Round
1972	Nov 12, 1972	San Francisco 49ers	24-21	at San Francisco 49ers	Week 9

1960s

Season	Date	Winner	Score	Site	Round
1969 (0-2)	Oct 26, 1969	San Francisco 49ers	24-21	at Baltimore Colts	Week 6
	Nov 16, 1969	San Francisco 49ers	20-17	at San Francisco 49ers	Week 9
1968 (2-0)	Sep 15, 1968	Baltimore Colts	27-10	at Baltimore Colts	Week 1
	Oct 13, 1968	Baltimore Colts	42-14	at San Francisco 49ers	Week 5
1967 (2-0)	Oct 1, 1967	Baltimore Colts	41-7	at Baltimore Colts	Week 3
	Nov 26, 1967	Baltimore Colts	26-9	at San Francisco 49ers	Week 11
1966 (2-0)	Sep 25, 1966	Baltimore Colts	36-14	at Baltimore Colts	Week 3
	Dec 18, 1966	Baltimore Colts	30-14	at San Francisco 49ers	Week 15
1965 (2-0)	Oct 3, 1965	Baltimore Colts	27-24	at Baltimore Colts	Week 3
	Oct 31, 1965	Baltimore Colts	34-28	at San Francisco 49ers	Week 7
1964 (2-0)	Nov 1, 1964	Baltimore Colts	37-7	at Baltimore Colts	Week 8
	Nov 29, 1964	Baltimore Colts	14-3	at San Francisco 49ers	Week 12
1963 (2-0)	Sep 22, 1963	Baltimore Colts	20-14	at San Francisco 49ers	Week 2
	Oct 13, 1963	Baltimore Colts	20-3	at Baltimore Colts	Week 5
1962 (1-1)	Oct 7, 1962	San Francisco 49ers	21-13	at Baltimore Colts	Week 4
	Nov 4, 1962	Baltimore Colts	22-3	at San Francisco 49ers	Week 8
1961 (2-0)	Dec 3, 1961	Baltimore Colts	20-17	at Baltimore Colts	Week 12
	Dec 16, 1961	Baltimore Colts	27-24	at San Francisco 49ers	Week 14
1960 (0-2)	Nov 27, 1960	San Francisco 49ers	30-22	at Baltimore Colts	Week 10
	Dec 18, 1960	San Francisco 49ers	34-10	at San Francisco 49ers	Week 13

1950s

Season	Date	Winner	Score	Site	Round
1959 (2-0)	Nov 22, 1959	Baltimore Colts	45-14	at Baltimore Colts	Week 9
	Dec 5, 1959	Baltimore Colts	34-14	at San Francisco 49ers	Week 11
1958 (1-1)	Nov 30, 1958	Baltimore Colts	35-27	at Baltimore Colts	Week 10
	Dec 14, 1958	San Francisco 49ers	21-12	at San Francisco 49ers	Week 12
1957 (1-1)	Nov 24, 1957	Baltimore Colts	27-21	at Baltimore Colts	Week 9
	Dec 8, 1957	San Francisco 49ers	17-13	at San Francisco 49ers	Week 11
1956 (0-2)	Dec 2, 1956	San Francisco 49ers	20-17	at Baltimore Colts	Week 10
	Dec 16, 1956	San Francisco 49ers	30-17	at San Francisco 49ers	Week 12
1955 (1-1)	Nov 27, 1955	Baltimore Colts	26-14	at Baltimore Colts	Week 10
	Dec 11, 1955	San Francisco 49ers	35-24	at San Francisco 49ers	Week 12
1954 (1-1)	Nov 28, 1954	Baltimore Colts	17-13	at Baltimore Colts	Week 10
	Dec 11, 1954	San Francisco 49ers	10-7	at San Francisco 49ers	Week 12
1953 (0-2)	Nov 29, 1953	San Francisco 49ers	38-21	at Baltimore Colts	Week 10
	Dec 13, 1953	San Francisco 49ers	45-14	at San Francisco 49ers	Week 12