Jacksonville Jaguars vs San Francisco 49ers

Jacksonville Jaguars 3

San Francisco 49ers leads 5-3

wins

1999 to 2025

Jacksonville Jaguars won the last meeting

San Francisco 49ers 5

Series timeline

▲ Jacksonville Jaguars ahead (peak +2) ▼ San Francisco 49ers ahead (peak +3)

Jacksonville Jaguars San Francisco 49ers Tie Postseason One meeting per cell

Longest streaks: Jacksonville Jaguars 2 (1999–2005), San Francisco 49ers 5 (2009–2023). Current: Jacksonville Jaguars 1.

Split	Jacksonville Jaguars record
Regular season	3-5
Hosted by Jacksonville Jaguars	2-3
Hosted by San Francisco 49ers	1-2
Last 8 seasons (1999 to 2025)	3-5
Largest Jacksonville Jaguars win	41-3 (1999)
Largest San Francisco 49ers win	42-10 (2013)

2020s

Season	Date	Winner	Score	Site	Round
2025	Sep 28, 2025	Jacksonville Jaguars	26-21	at San Francisco 49ers	Week 4
2023	Nov 12, 2023	San Francisco 49ers	34-3	at Jacksonville Jaguars	Week 10
2021	Nov 21, 2021	San Francisco 49ers	30-10	at Jacksonville Jaguars	Week 11

2010s

Season	Date	Winner	Score	Site	Round
2017	Dec 24, 2017	San Francisco 49ers	44-33	at San Francisco 49ers	Week 16
2013	Oct 27, 2013	San Francisco 49ers	42-10	at Jacksonville Jaguars	Week 8

2000s

Season	Date	Winner	Score	Site	Round
2009	Nov 29, 2009	San Francisco 49ers	20-3	at San Francisco 49ers	Week 12
2005	Dec 18, 2005	Jacksonville Jaguars	10-9	at Jacksonville Jaguars	Week 15

1990s

Season	Date	Winner	Score	Site	Round
1999	Sep 12, 1999	Jacksonville Jaguars	41-3	at Jacksonville Jaguars	Week 1